Author/Authors :
Michael J. Sofia، نويسنده , , Katrina Nelson، نويسنده , , David K. Herron، نويسنده , , Theodore Goodson، نويسنده , , Larry L. Froelich، نويسنده , , Stephen M. Spaethe، نويسنده , , Philip Marder، نويسنده , , Carlos R. Roman، نويسنده , , Jerome H. Fleisch، نويسنده ,
Abstract :
A series of 2-n-alkyl-4-ethyl-5-[6-methyl-6-(2H-tetrazol-5-yl)heptyloxy]phenols were prepared and shown to be potent leukotriene B4 (LTB4) receptor antagonists. They bound to the human neutrophil and guinea pig lung LTB4 receptors with high affinity. Each compound was also shown to be effective at antagonizing the effects of LTB4-induced integrin up-regulation on human neutrophils and on LTB4-mediated contraction of guinea pig lung parenchyma.
