Author/Authors :
Samuel Chackalamannil، نويسنده , , Yan Xia، نويسنده , , Yuguang Wang، نويسنده , , Hsingan Tsai، نويسنده , , Michael Czarniecki، نويسنده , , Suke Wang، نويسنده , , Anthony Clemmons، نويسنده , , Ho-Sam Ahn، نويسنده , , George Boykow، نويسنده ,
Abstract :
The synthesis and CETP inhibitory activity of a series of compounds related to wiedendiols (1a,1b) are reported. It is proposed that a two point pharmacophore consisting of a catechol group and a large hydrophobic anchor is necessary for activity.
