Author/Authors :
G. Erik Jagdmann Jr.، نويسنده , , Jean M. Defauw، نويسنده , , Yen-Shi Lai، نويسنده , , Heidi M. Crane، نويسنده , , Steven E. Hall، نويسنده , , John A. Buben، نويسنده , , Hong Hu، نويسنده , , Paul A. Gosnell، نويسنده ,
Abstract :
Balanol ((−)-1) is a potent protein kinase inhibitory natural product isolated from the fungus Verticillium balanoides. The presence of an ester functionality in this molecule has prompted concern over the metabolic stability of balanol, and has led to a search for active analogs lacking this moiety. The synthesis and serum stability for some of these is presented herein.
