5,6,7,8-Tetrahydroquinolones as antagonists at the glycine site of the NMDA receptor

The effect of reducing the benzo ring of a series of 4-hydroxyquinolone Glycine/NMDA antagonists is described. It is important that the ring be present, but not that it is aromatic. Provided that the correct lipophilic interactions are present, high affinity is found in 4-hydroxy-5,6,7,8-tetrahydroquinolones.