Pharmacological evaluation of UK-14,304 analogs at cloned human α adrenergic receptors

As a part of a program directed at the identification of subtype selective α2 agonists, a series of analogs of UK-14,304 (1) were synthesized. Binding affinities and functional efficacies were measured at cloned human α adrenergic receptors. A number of analogs showed high binding affinity and good selectivity for the human α2A receptor subtype.