Title of article
Design, synthesis and biological activity of some 4-DAMP- related compounds
Author/Authors
Vincenzo Tumiatti، نويسنده , , Santi Spampinato، نويسنده , , Maurizio Recanatini، نويسنده , , Anna Minarini، نويسنده , , Carlo Melchiorre، نويسنده , , Alberto Chiarini، نويسنده , , Roberta Budriesi، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2325
To page
2330
Abstract
Two constrained analogues (4a and 4b) of both 4-DAMP (1) and spiro-DAMP (2) were designed, and their biological profiles at muscarinic receptor subtypes were assessed by functional and binding assays. It turned out that these constrained analogues display a modest, if any, M2/M3 selectivity ratio. However, most interestingly, they proved to be highly selective for muscarinic M1 receptors.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787703
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