Author/Authors :
Robert A. Zambias، نويسنده , , Catherine James، نويسنده , , Milton L. Hammond، نويسنده , , George K. Abruzzo، نويسنده , , Kenneth F. Bartizal، نويسنده , , Karl H. Nollstadt، نويسنده , , Cameron Douglas، نويسنده , , Jean Marrinan، نويسنده , , James M. Balkovec، نويسنده ,
Abstract :
Selective methanolysis or dehydration followed by reduction of the 3-hydroxyglutamine residue of pneumocandin B0 (1) or its dideoxy analog 5 (L-692,289) gave the methyl 3-hydroxyglutamate and 3-hydroxyornithine analogs 6 and 9, respectively. Further derivatization of these analogs allowed a study of the SAR at this position. In general, carboxylic acid-containing derivatives were poorer antifungal agents than neutral derivatives while amine-bearing analogs displayed the greatest potency.
