Silicon-mediated inactivation of semicarbazide-sensitive amine oxidase

Several organosilicon amines were synthesized as potential mechanism-based inhibitors of semicarbazide-sensitive amine oxidase (SSAO) prepared from rat aorta. 2-[Dimethyl(2-phenylethyl)silyl]-methanamine, hydrochloride produced potent time-dependent inhibition of SSAO. A potential mechanism is proposed to explain SSAO inactivation by organosilicon amines.