Title of article :
Isolation, structure determination and squalene synthase activity of L-731,120 and L-731,128, alkyl citrate analogs of zaragozic acids A and B
Author/Authors :
Guy H. Harris، نويسنده , , Claude Dufresne، نويسنده , , Henry Joshua، نويسنده , , Leslie A. Koch، نويسنده , , Deborah L. Zink، نويسنده , , Peter M. Salmon، نويسنده , , Kent E. G?klen، نويسنده , , Marc M. Kurtz، نويسنده , , Deborah J. Rew، نويسنده , , James D. Bergstrom، نويسنده , , Kenneth E. Wilson، نويسنده ,
Abstract :
Two new alkyl citrates, L-731,120 and L-731,128, with alkyl chains corresponding to those of zaragozic acids A and B, were isolated as minor components of large scale fungal fermentations producing zaragozic acid A and B. They are submicromolar inhibitors of squalene synthase in vitro.
