Title of article :
The synthesis of pyrazolo[4,3-c]- and imidazo[4,5-c]-Aryl[e]fused pyridines as structural analogues of 4-aminonicotinoates
Author/Authors :
Christopher D. Benham، نويسنده , , Thomas P. Blackburn، نويسنده , , Amanda Johns، نويسنده , , Nikesh R. Kotecha، نويسنده , , Roger T. Martin، نويسنده , , David R. Thomas، نويسنده , , Mervyn Thompson، نويسنده , , Robert W. Ward، نويسنده ,
Abstract :
A series of 4-aminobenzothienopyridine-3-carboxylates 4 to 10 has been prepared and the SAR of these GABAA modulators discussed. Replacement of the 4-aminonicotinoate moiety by imidazo [4,5-c] ring fusion provides potent bioisosteres 12 to 14.
