Title of article
Methanodibenzosuberylpiperazines as potent multidrug resistance reversal agents
Author/Authors
J. R. Pfister، نويسنده , , F. Makra، نويسنده , , A. V. Muehldorf، نويسنده , , H. Wu، نويسنده , , J. T. Nelson، نويسنده , , P. Cheung، نويسنده , , N. A. Bruno، نويسنده , , S. M. Casey، نويسنده , , N. Zutshi، نويسنده , , D. L. Slate، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
2473
To page
2476
Abstract
Annellation of a cyclopropyl group to the dibenzosuberane moiety of the prototypical agent MS-073 afforded potent multiple drug resistance modulators. The chiral differentiation observed for the enantiomers of some of these compounds points to a specific interaction with the drug efflux pump, glycoprotein p 170, in contrast to the less specific membrane interaction seen with less potent agents.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787730
Link To Document