Author/Authors :
Gregory Merriman، نويسنده , , John J. Tegeler، نويسنده , , R. Richard L. Hamer، نويسنده , , Barbara S. Rauckman، نويسنده , , Brian S. Freed، نويسنده , , Ellen S. Kurtz، نويسنده , , Steven C. Bailey، نويسنده , , Marie Ortega-Nanos، نويسنده , , Penelope A. Przekop، نويسنده , , Luther Hellyer، نويسنده ,
Abstract :
Recently we identified three promising topically active antiinflammatory agents (2, 3, and 4) from a series of racemic aryl-sphingolipids that inhibit protein kinase C (PKC). We now wish to report the enantioselective synthesis of the aforementioned leads and their comparative biological profile. The individual enantiomers examined are equipotent to their racemate in vitro and in vivo.
