Author/Authors :
John H. Tatlock، نويسنده , , Vincent J. Kalish، نويسنده , , H. E. Parge، نويسنده , , Daniel R. Knighton، نويسنده , , Richard E. Showalter، نويسنده , , Christina T. Lewis، نويسنده , , J. V. French، نويسنده , , J. Ernest Villafranca، نويسنده ,
Abstract :
The preparation and evaluation of potent small molecule inhibitors of FKBP-12 rotamase activity is described. These ligands contain many of the structural features of the FK506 pyranose ring region, yet are synthetically more accessible. The versatility of these FKBP-12 ligands is demonstrated with respect to effector domain exploration.
