Title of article
The serotonin 5-HT4 receptor: Part 3: Design and pharmacological evaluation of a new class of antagonists
Author/Authors
K. -H. Buchheit، نويسنده , , F. Klein، نويسنده , , E. Kl?ppner، نويسنده , , H. -J. Pfannkuche، نويسنده , , H. Mattes، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2495
To page
2500
Abstract
The design, synthesis and pharmacological activity of a new class of potent and selective 5-HT4 receptor antagonists containing an indole nucleus linked to a carbazimidamide are presented. 4c, a representative member of our new class is a potent competitive antagonist at 5-HT4 receptors with a pA2 value of 8.4, displaying selectivity (ranging from 20 to over 1000 fold) versus other serotonin receptor subtypes.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787734
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