Enzymatic synthesis of YIGSR — laminin pentapeptide fragment- derivatives

An enzymatic synthesis of Ac-Tyr-Ile-Gly-Ser-Arg-OH, its amide and p-nitroanilide starting with Boc-Ile-Gly-Ser-OCH3 is described. The reactions were performed in organic solvents using subtilisin and α-chymotrypsin sorbed on macroporous silica surface as the catalysts.