Title of article :
N-substituted glycines as replacements for proline in tripeptide aldehyde thrombin inhibitors
Author/Authors :
Aaron L. Schacht، نويسنده , , Michael R. Wiley، نويسنده , , Nickolay Chirgadze، نويسنده , , David Clawson، نويسنده , , Trelia J. Craft، نويسنده , , William J. Coffman، نويسنده , , Noel D. Jones، نويسنده , , Donnetta Gifford-Moore، نويسنده , , Jennifer Olkowski، نويسنده , , Robert T. Shuman، نويسنده , , Gerald F. Smith، نويسنده , , Leonard C. Weir، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
6
From page :
2529
To page :
2534
Abstract :
We have prepared a series of tripeptide arginine aldehydes in which the P2 proline has been replaced with a variety of N-substituted glycines. The effects of these modifications on thrombin inhibitory potency and serine protease selectivity were evaluated.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Serial Year :
1995
Journal title :
Bioorganic & Medicinal Chemistry Letters
Record number :
787741
Link To Document :
https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=787741
بازگشت