Title of article
N-substituted glycines as replacements for proline in tripeptide aldehyde thrombin inhibitors
Author/Authors
Aaron L. Schacht، نويسنده , , Michael R. Wiley، نويسنده , , Nickolay Chirgadze، نويسنده , , David Clawson، نويسنده , , Trelia J. Craft، نويسنده , , William J. Coffman، نويسنده , , Noel D. Jones، نويسنده , , Donnetta Gifford-Moore، نويسنده , , Jennifer Olkowski، نويسنده , , Robert T. Shuman، نويسنده , , Gerald F. Smith، نويسنده , , Leonard C. Weir، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2529
To page
2534
Abstract
We have prepared a series of tripeptide arginine aldehydes in which the P2 proline has been replaced with a variety of N-substituted glycines. The effects of these modifications on thrombin inhibitory potency and serine protease selectivity were evaluated.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787741
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