Title of article
4,5-Dihydro-4-oxo-3H-imidazo[4,5-c]pyridines: potent arylacetic acid-derived AT1 antagonists with improved affinity for the AT2 receptor
Author/Authors
Werner W. K. R. Mederski، نويسنده , , Dieter Dorsch، نويسنده , , Mathias Osswald، نويسنده , , Norbert Beier، نويسنده , , Ingeborg Lues، نويسنده , , Klaus-Otto Minck، نويسنده , , Pierre Schelling، نويسنده , , Bernhard J. Ladstetter، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2665
To page
2670
Abstract
The replacement of dimethylacetamide with arylacetic acid esters and acetamides at the imidazo[4,5-c]pyridine 5-position of EMD 66684 2 imparts affinity for the AT2 receptor. The highest affinity was found with the phenylacetic acid isopropylester moiety, which led to compound 7c with an IC50 value of 32 nM (AT2) and an AT2/AT1 ratio of 5.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787764
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