Title of article
Synthesis and biological evaluation of an alkenyldiarylmethane (ADAM) which acts as a novel non-nucleoside HIV-1 reverse transcriptase inhibitor
Author/Authors
Mark Cushman، نويسنده , , Marek Golebiewski، نويسنده , , Robert W. Buckheit Jr.، نويسنده , , Lisa Graham، نويسنده , , William G. Rice، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
4
From page
2713
To page
2716
Abstract
ADAM, a novel non-nucleoside HIV-1 reverse transcriptase inhibitor, was synthesized and found to inhibit a variety of HIV-1 strains. In common with other known NNRTIs, ADAM is inactive against HIV-2, and it is much more active as an inhibitor of HIV-1 reverse transcriptase with poly(rC).oligo(dG) as the template/primer than it is with poly(rA).oligo(dT) as the template/primer.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787772
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