Synthesis and biological evaluation of an alkenyldiarylmethane (ADAM) which acts as a novel non-nucleoside HIV-1 reverse transcriptase inhibitor

ADAM, a novel non-nucleoside HIV-1 reverse transcriptase inhibitor, was synthesized and found to inhibit a variety of HIV-1 strains. In common with other known NNRTIs, ADAM is inactive against HIV-2, and it is much more active as an inhibitor of HIV-1 reverse transcriptase with poly(rC).oligo(dG) as the template/primer than it is with poly(rA).oligo(dT) as the template/primer.