Title of article :
The anti-rheumatic potential of a series of 2,4-di-substituted-4H-naphtho[1,2-b]pyran-3-carbonitriles
Author/Authors :
Colin W. Smith، نويسنده , , James M. Bailey ، نويسنده , , Michael E. J. Billingham، نويسنده , , Srinivasan Chandrasekhar، نويسنده , , Colin P. Dell، نويسنده , , Anita K. Harvey، نويسنده , , Caroline A. Hicks، نويسنده , , Ann E. Kingston، نويسنده , , Graham N. Wishart، نويسنده ,
Abstract :
A new series of naphtho[1,2-b]pyran-3-carbonitriles with enhanced stability under acid conditions has been synthesised and examined for antiproliferative and anti-inflammatory activity. 4-(3-nitrophenyl)-2-(N-succinimido)-4H-naphtho[1,2-b]pyran-3-carbonitrile, 10, has proved to be acid stable and still retains biological activity.
