Title of article
Ly316340: A potent HIV-1 protease inhibitor containing a high affinity octahydrothienopyridine hydroxyethylamine isostere
Author/Authors
John E. Munroe، نويسنده , , William J. Hornback، نويسنده , , Jack B. Campbell، نويسنده , , Michael A. Ouellette، نويسنده , , Steve D. Hatch، نويسنده , , Mark A. Muesing، نويسنده , , Mary Ann Wiskerchen، نويسنده , , Angela J. Baxter، نويسنده , , Ken Su، نويسنده , , Kristina Campanale، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2885
To page
2890
Abstract
Replacement of the decahydroisoquinoline group contained in Ro 31-8959 by a cis-octahydrothienopyridine moiety has provided a high affinity hydroxyethylamine isostere for use in HIV-1 protease inhibitors. Further gains in potency have been realized by incorporation of a sulfur atom into the P1 benzyl group. Modification by a key P2 ligand provided LY316440, a potent, orally absorbed inhibitor of HIV-1 protease.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787804
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