Title of article
Synthesis and pharmacokinetics of potent carbamate HIV-1 protease inhibitors containing novel high affinity hydroxyethylamine isosteres
Author/Authors
William J. Hornback، نويسنده , , John E. Munroe، نويسنده , , Timothy A. Shepherd، نويسنده , , Steve D. Hatch، نويسنده , , Mark A. Muesing، نويسنده , , MaryAnn Wiskerchen، نويسنده , , Joseph M. Colacino، نويسنده , , Angela J. Baxter، نويسنده , , Kenneth S. Su، نويسنده , , Kristina M. Campanale، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1995
Pages
6
From page
2891
To page
2896
Abstract
Using the hydroxyethylamine isosteres 1 and 2 containing the novel cis-octahydrothienopyridine moiety, substantial enhancement of binding potencies for HIV-1 protease inhibitors which incorporate carbamate linked heterocyclic P2 ligands has been realized. This increase in binding has led to a very potent antiviral compound (LY326188). The pharmacokinetics of selected derivatives are detailed in this report.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1995
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787805
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