Author/Authors :
Sundeep Dugar، نويسنده , , Michael P. Kirkup، نويسنده , , John W. Clader، نويسنده , , Sue-Ing Lin، نويسنده , , Razia Rizvi، نويسنده , , Mark E. Snow، نويسنده , , Harry R. Davis Jr.، نويسنده , , Stuart W. McCombie، نويسنده ,
Abstract :
Our search for potent cholesterol absorption inhibitors led to the discovery of the β-lactam SCH 48461. Structure activity relationship studies prompted us to this study of γ-lactams, ring homologs of β-lactam SCH 48461, to determine their potential as cholesterol absorption inhibitors. The results indicate that the γ-lactams have moderate cholesterol absorption inhibitory properties.
