1,5-Benzodiazepines as CCK-B antagonists. Effect of halogen substitution at the benzo-fused ring on potency and selectivity

Some 1,5-benzodiazepines substituted with halogen atoms in the benzo-fused ring were synthesized and evaluated as CCK antagonists at both CCK-A and CCK-B receptors. Details of the binding of these agents to both receptors are reported and discussed briefly.