Synthesis of thiophenol derivatives as inhibitors of human collagenase
Author/Authors :
Ian Hughes، نويسنده , , Gregory P. Harper، نويسنده , , Eric H. Karran، نويسنده , , Roger E. Markwell، نويسنده , , Anette J. Miles-Williams، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1995
Pages :
4
From page :
3039
To page :
3042
Abstract :
A series of peptidomimetic thiophenol derivatives has been prepared and evaluated in vitro as inhibitors of human fibroblast collagenase. Many of these compounds have IC50 values in the sub-micromolar range.
