Synthesis and biological properties of carboranylaziridines bearing cascade polyols

1-(Carboranyl)-3-(2-methylaziridino)-2-propanols bearing cascade polyols, MACB(OH)2 and MACB(OH)4, were prepared in order to increase water solubility in comparison with MACB itself. By attaching cascade polyols as a water solubilizing element, cytotoxicity decreased and boron uptake by cancer cells increased.