Author/Authors :
Masayuki Kato، نويسنده , , Shigetaka Nishino، نويسنده , , Mitsuko Ohno، نويسنده , , Shinichi Fukuyama، نويسنده , , Yasuhiro Kita، نويسنده , , Yoshimi Hirasawa، نويسنده , , Isao Nakanishi، نويسنده , , Hisashi Takasugi، نويسنده , , Kazuo Sakane، نويسنده ,
Abstract :
The synthesis and structure-stability relationships of a series of novel FK409 derivatives (1, 2, and 3) are described. The rates of decomposition in aqueous solution (pH 8.0, 30 °C) were parallel with those of spontaneous NO release measured by ESR spectroscopy using carboxy-PTIO. The compounds can cover a wide range of NO releasing rates by appropriate modification of the molecule.
