Atropisomeric carbamoyl type inhibitors of pancreatic cholesterol esterase

Atropisomers of 1,1′-bi-2-naphthyl-2,2′-di-N-butylcarbamate (1), 1,1′-bi-2-naphthyl-2-N-butylcarbamate-2′-ol (2), and 1,1′-bi-2-naphthyl-2-N-butylcarbamate-2′-butyrate (3) as active site-directed irreversible inhibitors of pancreatic cholesterol esterase are investigated for values of the dissociation constant (KI), the carbamylation constant (k2), and the bimolecular rate constant (ki).