Author/Authors :
C. Smith، نويسنده , , M. J. Ashton، نويسنده , , R. C. Bush، نويسنده , , V. Facchini، نويسنده , , N. V. Harris، نويسنده , , T. W. Hart، نويسنده , , R. Jordan، نويسنده , , R. MacKenzie، نويسنده , , D. Riddell، نويسنده ,
Abstract :
RP 73163 5 the major metabolite of the ACAT inhibitor RP 76076 3 retains ACAT activity. This alkylsulphinyl-4,5-diphenyl-1H-imidazole has higher systemic bioavailability than the parent thioether, with plasma levels of parent compound in certain species exceeding the IC50 required for inhibition of hepatic, intestinal, artery, adrenal and macrophage ACAT for up to twelve hours after oral dosing.
