Title of article
RP 73163: A bioavailable alkylsulphinyl-diphenylimidazole ACAT inhibitor
Author/Authors
C. Smith، نويسنده , , M. J. Ashton، نويسنده , , R. C. Bush، نويسنده , , V. Facchini، نويسنده , , N. V. Harris، نويسنده , , T. W. Hart، نويسنده , , R. Jordan، نويسنده , , R. MacKenzie، نويسنده , , D. Riddell، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
47
To page
50
Abstract
RP 73163 5 the major metabolite of the ACAT inhibitor RP 76076 3 retains ACAT activity. This alkylsulphinyl-4,5-diphenyl-1H-imidazole has higher systemic bioavailability than the parent thioether, with plasma levels of parent compound in certain species exceeding the IC50 required for inhibition of hepatic, intestinal, artery, adrenal and macrophage ACAT for up to twelve hours after oral dosing.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787854
Link To Document