Title of article
Platelet glycoprotein IIb–IIIa receptor (GPIIb–IIIa) antagonists derived from amidinoindoles
Author/Authors
Daniel J. Sall، نويسنده , , Ann E. Arfsten، نويسنده , , Dennis R. Berry، نويسنده , , Michael L. Denney، نويسنده , , Cathy S. Harms، نويسنده , , Jefferson R. McCowan، نويسنده , , Judith K. Ray، نويسنده , , Robert M. Scarborough، نويسنده , , Suzane L. Um، نويسنده , , Barbara G. Utterback، نويسنده , , Joseph A. Jakubowski، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
81
To page
86
Abstract
A series of substituted amidinoindoles have been prepared as mimics of the RGD sequence and were studied as antagonists of the platelet glycoprotein IIb–IIIa receptor (GPIIb–IIIa). The agents were potent and selective antagonists of GPIIb–IIIa. Compared to their acyclic counterparts, the amidinoindole series bound with 10- to 20-fold greater affinity, indicating the advantages of added conformational restriction and/or hydrophobicity in the basic region of RGD mimics.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787861
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