Author/Authors :
Argyrios G. Arvanitis، نويسنده , , Everett L. Scholfield، نويسنده , , Dimitri Grigoriadis، نويسنده , , Peter G. Heytler، نويسنده , , Jack Bowdle، نويسنده , , Robert J. Chorvat، نويسنده ,
Abstract :
A series of alkylbenzylethers of substituted hydroquinone analogs of 4-(3-chlorophenyl methyloxy)-phenoxybutyronitrile I, and alcohol II were synthesized as monoamine oxidase (MAO) inhibitors. Incorporation of electron-withdrawing groups on the hydroquinone afforded compounds with higher levels of activity and selectivity than I or II for MAO B inhibition.
