Oximes: A new class of methoxytetrahydropyranyl inhibitors of leukotriene biosynthesis with high in vitro and in vivo potency

Work aimed at further improving the in vivo activity of methoxytetrahydropyranyl inhibitors of leukotriene biosynthesis has led to the discovery of a series of oximes, members of which are more potent in vivo than ZD2138.