Synthesis of water-soluble prodrugs of the cytotoxic agent Combretastatin A4
Author/Authors :
Simon B Bedford، نويسنده , , Charmaine P Quarterman، نويسنده , , Daniel L Rathbone، نويسنده , , John F. Slack ، نويسنده , , Roger J Griffin، نويسنده , , Malcolm F G Stevens، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Pages :
4
From page :
157
To page :
160
Abstract :
Water-soluble phosphate and glycine carbamate prodrugs of the cytotoxic agent Combretastatin A4 (1) have been prepared. The phosphate prodrug was degraded slowly in plasma at 37°C. The degradation was accelerated by the addition of alkaline phosphatase.
