Title of article :
Synthesis, enzymatic phosphorylation and antiviral activity of acyclic dienyl phosphonate derivatives of guanine
Author/Authors :
Jean-François Navé، نويسنده , , Patrick J. Casara، نويسنده , , Debra L. Taylor، نويسنده , , A. Stanley Tyms، نويسنده , , Michael Kenny، نويسنده , , Serge HalazyS، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Abstract :
The synthesis, phosphorylation by guanylate kinase, anti HIV-1 and anti-herpesvirus activity of two acyclic dienyl phosphonate derivatives of guanine are described. (E)-9-(5-phosphono-3-methylene-4-pentenyl)guanine (4) was identified as an excellent substrate of guanylate kinase and a significant inhibitor of HIV-1 replication.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
