Title of article
Synthesis and biological activity of conformationally constrained sialyl Lewis X analogues with reduced carbohydrate character
Author/Authors
Mark J. Bamford، نويسنده , , Michael Bird، نويسنده , , Paul M. Gore، نويسنده , , Duncan S. Holmes، نويسنده , , Richard Priest، نويسنده , , Jeremy C. Prodger، نويسنده , , Victoria Saez، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
239
To page
244
Abstract
Two conformationally constrained analogues of sialyl Lewis X have been synthesised in which the GlcNAc residue has been replaced with cyclohexyl and phenyl rings. The cyclohexyl derived compound was equipotent to sLex and sLea in vitro, suggesting the main role of the GlcNAc residue in sLex is conformational, and represents a simplified inhibitor of adhesion.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787892
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