Title of article
Synthesis and biological activity of the neuronal calcium channel blocker 2-amino-1-(2,5-dimethoxyphenyl)-5-trifluoromethyl benzimidazole (NS-649)
Author/Authors
Thomas Varming، نويسنده , , Palle Christophersen، نويسنده , , Arne M?ller، نويسنده , , Dan Peters، نويسنده , , Oskar Axelsson، نويسنده , , Elsebet ?. Nielsen، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
245
To page
248
Abstract
The substituted benzimidazole, NS-649, has been shown to be a blocker of neuronal calcium channels in patch-clamp studies. NS-649 dose-dependently inhibited release of -aspartate from cerebellar granule neurons. The neuroprotective effect of this compound in in vitro and in vivo models of ischemia was demonstrated.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787893
Link To Document