Title of article
Design and synthesis of ring-constrained boropeptide thrombin inhibitors
Author/Authors
John M. Fevig، نويسنده , , Matthew M. Abelman، نويسنده , , David R. Brittelli، نويسنده , , Charles A. Kettner، نويسنده , , Robert M. Knabb، نويسنده , , Patricia C. Weber، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
295
To page
300
Abstract
Ring-constrained boropeptide thrombin inhibitors were designed using information from the X-ray crystal structure of 1 (3-Phenylpropionyl-Pro-boroLys-OH •HCl) bound to thrombin. The constraints utilized cyclohexane and pyrrolidine rings to preorganize an aromatic ring in an orientation allowing optimum edge-to-face interaction with the tryptophan 215 side chain located in the S3 specificity pocket of thrombin.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787904
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