Title of article
Inhibition of matrix metalloproteinases by P1 substituted N-carboxyalkyl dipeptides
Author/Authors
Kevin T. Chapman، نويسنده , , Jennifer Wales، نويسنده , , Soumya P. Sahoo، نويسنده , , Lisa M. Niedzwiecki، نويسنده , , Maria Izquierdo-Martin، نويسنده , , Benedict C. Chang، نويسنده , , Richard K. Harrison، نويسنده , , Ross L. Stein، نويسنده , , William K. Hagmann، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
329
To page
332
Abstract
Aroyl and arylacyl aminoalkyl substitutents at the P1 position of N-carboxyalkyl dipeptides were found to enhance potency and selectivity for stromelysin-1 (MMP-3). In particular, the phthalimidobutyl and phenylpropanoylaminopropyl groups offered inhibitors of MMP-3 with Kiʹs of 10nM.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787911
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