Author/Authors :
Daniela Pinzani، نويسنده , , Anna M. Papini، نويسنده , , Maria E. Vallecchi، نويسنده , , Mario Chelli، نويسنده , , Mauro Ginanneschi، نويسنده , , Gianfranco Rapi، نويسنده , , Laura Quartara، نويسنده , , Riccardo Patacchini، نويسنده , , Carlo A. Maggi، نويسنده , , Federico M. Arcamone، نويسنده ,
Abstract :
The influence of glycosylation on the structure-activity relationship of the tachykinin antagonist MEN 10376 and of its minimal active fragment MEN 10414 was investigated. The antagonist activity was preserved only when β- -glucosylated Tyr, Ser and Asn were added to the N-terminal position of MEN 10376, while the modification of the side chain of the Tyr2 induced a dramatic decrease in affinity.
