Title of article
Unsaturated thioacetic acids as novel mechanism-based inhibitors of peptidylglycine α-hydroxylating monooxygenase
Author/Authors
P. Casara، نويسنده , , A. Ganzhorn، نويسنده , , C. Philippo، نويسنده , , M-C. Chanal، نويسنده , , C. Danzin، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
393
To page
396
Abstract
Several unsaturated thioacetic acids were synthesized as potential mechanism-based inhibitors of peptidyglycine α-hydroxylating monooxygenase (PHM) prepared from horse serum. Trans-styrylthioacetic acid produced potent time-dependent inhibition of PHM. Potential mechanisms are proposed to explain PHM inactivation by unsaturated thioacetic acids.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787924
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