Polyanion inhibitors of human immunodeficiency virus. Part IV. - polymerized anionic surfactants: Influence of the density and distribution of anionic groups on the antiviral activity

The synthesis of a series of new polyamions, via γ-polymerization, of ω-unsaturated multi-charged anionic surfactants, has been realized. These polyanions were evaluated for their activity against HIV-1. All tested compounds proved active without presenting toxicity to the host cells (CEM-4 or MT-4).