Title of article :
J-104,123, a novel and orally-active inhibitor of squalene synthase: Stereoselective synthesis and cholesterol lowering effects in dogs
Author/Authors :
Yoshikazu Iwasawa، نويسنده , , Jun Shibata، نويسنده , , Morihiro Mitsuya، نويسنده , , Hitoshi Masaki، نويسنده , , Masahiro Hayashi، نويسنده , , Tetsuya Kanno، نويسنده , , Yoshio Sawasaki، نويسنده , , Akihiro Hisaka، نويسنده , , Toshio Kamei، نويسنده , , Koji Tomimoto، نويسنده ,
Abstract :
J-104,123, a potent inhibitor of squalene synthase having monocarboxylic acid structure, was discovered by chemical modification of J-104,118. An oral dose of J-104,123 lowered serum cholesterol levels in dogs. J-104,123 was synthesized stereoselectively from methyl (R)-3-hydroxybutyrate.
