Title of article
Synthesis and biological evaluation of a new series of dihydrofolate reductase inhibitors based on the 4-(2,6-diamino-5-pyrimidinyl)alkyl-L-glutamic acid structure
Author/Authors
Lynn S. Gossett، نويسنده , , Lillian L. Habeck، نويسنده , , Susan B. Gates، نويسنده , , Sherri L. Andis، نويسنده , , John F. Worzalla، نويسنده , , Richard M. Schultz، نويسنده , , Laurane G. Mendelsonn، نويسنده , , William Kohler، نويسنده , , Manohar Ratnam، نويسنده , , Gerald B. Grindey، نويسنده , , Chuan Shih، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
4
From page
473
To page
476
Abstract
Abstract
A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a monocyclic pyrimidine ring.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787940
Link To Document