Author/Authors :
Lynn S. Gossett، نويسنده , , Lillian L. Habeck، نويسنده , , Susan B. Gates، نويسنده , , Sherri L. Andis، نويسنده , , John F. Worzalla، نويسنده , , Richard M. Schultz، نويسنده , , Laurane G. Mendelsonn، نويسنده , , William Kohler، نويسنده , , Manohar Ratnam، نويسنده , , Gerald B. Grindey، نويسنده , , Chuan Shih، نويسنده ,
Abstract :
Abstract
A novel series of dihydrofolate reductase inhibitors was uncovered during an expansion of the SAR of 5,10-dideazatetrahydrofolic acid, and their biological activity was evaluated. These new analogs do not possess an oxygen at the 4 position and contain a monocyclic pyrimidine ring.
