Title of article
Synthesis and biological activity of novel sialyl-lewisX conjugates
Author/Authors
Ulrich Sprengard، نويسنده , , Horst Kunz، نويسنده , , Christoph Hüls، نويسنده , , Wolfgang Schmidt، نويسنده , , Dirk Seiffge، نويسنده , , Gerhand Kretzshmar، نويسنده ,
Issue Information
روزنامه با شماره پیاپی سال 1996
Pages
6
From page
509
To page
514
Abstract
Novel sialyl LewisX conjugates have been synthesized and evaluated as inhibitors of E- and P-selectin mediated cell adhesion in cell culture assays. The most potent conjugate in the static inhibition assays exhibited a significant and dose-dependent pharmacological potency as inhibitor of the edotoxin-induced leukocyte adhesion to the endothelium of postcapillary venules in rats.
Journal title
Bioorganic & Medicinal Chemistry Letters
Serial Year
1996
Journal title
Bioorganic & Medicinal Chemistry Letters
Record number
787947
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