Author/Authors :
Ulrich Sprengard، نويسنده , , Horst Kunz، نويسنده , , Christoph Hüls، نويسنده , , Wolfgang Schmidt، نويسنده , , Dirk Seiffge، نويسنده , , Gerhand Kretzshmar، نويسنده ,
Abstract :
Novel sialyl LewisX conjugates have been synthesized and evaluated as inhibitors of E- and P-selectin mediated cell adhesion in cell culture assays. The most potent conjugate in the static inhibition assays exhibited a significant and dose-dependent pharmacological potency as inhibitor of the edotoxin-induced leukocyte adhesion to the endothelium of postcapillary venules in rats.
