Author/Authors :
Tsuyoshi Ohba، نويسنده , , Naoki Tsuchiya، نويسنده , , Kuniko Nishimura، نويسنده , , Eitatsu Ikeda، نويسنده , , Jun Wakayama، نويسنده , , Hisashi Takei، نويسنده ,
Abstract :
The peptidyl ester derivatives of 2,2-dichlorocyclopropanol and the amide derivative of 2,2-dichlorocyclopropylamine were prepred as novel mechanism-based inactivators of α-chymotrypsin. The esters inactivated α-chymotrypsin irreversibly but the amide did not show any irreversible inhibitory activity toward α-chymotrypsin.
