Trishomocubanes, a new class of selective and high affinity ligands for the sigma binding site

The synthesis, receptor binding, and preliminary structural characterisation of trishomocubanes of types pentacyclo[5.4.0.02,6.03,10.05,9]undecylamines- and 4-azahexacyclo[5.4.1.02,6.03,10.05,9.08,11]dodecanes are described. These ligands demonstrated high selectivity and affinity for the sigma binding site.