Title of article :
Optimization of retro-thiorphan for inhibition of endothelin converting enzyme
Author/Authors :
Paivi J. Kukkola، نويسنده , , Natalie A. Bilci، نويسنده , , W. X. Kozak، نويسنده , , Paula Savage، نويسنده , , Arco Y. Jeng، نويسنده ,
Issue Information :
روزنامه با شماره پیاپی سال 1996
Abstract :
The structural requirements of retro-thiorphan, N-[1R,S-benzyl-2-mercaptoethyl]malonamic acid 2, analogs for the inhibition of endothelin converting enzyme (ECE) were investigated. Although based on a single amino acid residue, N-[1R-(1H-indol-3-ylmethyl)-2-mercaptoethyl]-2-phenylacetamide 28 was found to be two times more potent than the widely utilized reference inhibitor phosphoramidon.
Journal title :
Bioorganic & Medicinal Chemistry Letters
Journal title :
Bioorganic & Medicinal Chemistry Letters
