Synthesis and in vitro cytotoxicity of cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxy- or -3,4-dihydroxypyrrolidine]platinum(II)

cis-Dichloro[(2S,3R,4S)-2-aminomethyl-3,4-(O-isopropylidene)dihydroxypyrrolidine]platinum(II) (1) and cis-dichloro[(2S,3R,4S)-2-aminomethyl-3,4-dihydroxypyrrolidine]platinum(II) (2) have been synthesized and evaluated for their in vitro cytotoxicity against cisplatin-sensitive and -resistant L1210 murine leukemia cell lines and human tumor cell lines. The complex 1 showed high cytotoxicity against human cancer cell lines, A 549, SK-OV-3, and XF 498 and much lower cross-resistance against cisplatin-resistant L1210 cells than cisplatin and carboplatin.