Author/Authors :
Masayoshi Okano، نويسنده , , Narihiko Fukamiya، نويسنده , , Kiyoshi Tagahara، نويسنده , , L. Mark Cosentino، نويسنده , , Thomas Tung-Ying Lee، نويسنده , , Susan Morris-Natschke، نويسنده , , Kuo-Hsiung Lee، نويسنده ,
Abstract :
Eighteen quassinoid glycosides and nine known quassinoids were tested for inhibitory activity against HIV replication in H9 lymphocytic cells. Of the compounds tested, shinjulactone C (20) demonstrated the highest anti-HIV activity (EC50 = 10.6 μM) in the absence of cytotoxicity with a therapeutic index of>25.
