Author/Authors :
Gary C. Look، نويسنده , , John R. Schullek، نويسنده , , Christopher P. Holmes، نويسنده , , Jason P. Chinn، نويسنده , , Eric M. Gordon، نويسنده , , Mark A. Gallop، نويسنده ,
Abstract :
Three 4-thiazolidinone libraries, each containing up to 540 compounds, were prepared and assayed for inhibition of the enzyme cyclooxygenase-1 (COX-1). Deconvolution analysis led to the identification of a compound that is equipotent with the commercial COX-1 inhibitors ibuprofen and phenylbutazone
