Author/Authors :
Samarendra N. Maiti، نويسنده , , David P. Czajkowski، نويسنده , , Narender A. V. Reddy، نويسنده , , Paul Spevak، نويسنده , , Jadwiga Kaleta، نويسنده , , Ronald G. Micetich، نويسنده ,
Abstract :
Treatment of 3-methyl-3-cephem sulphone with sodium hydride followed by carbon disulphide and alkyl halide provides an entry to 2-(1,3-diothiolan-2-ylidene)-cephem derivatives, which are new potent inhibitors of HSE.